Oncotarget Manifests Itself as a Platform That Aids in the Fight against Diseases

Aging is the process in which animals, human beings and plants, which have ceased growing, become older. In human beings particularly, aging is considered as a risk factor as it increases susceptibility to get diseases and even death. The causes of aging are not well known but there are numerous theories that discuss this. Most of the theories relate aging to the damage concept. This explains that continuous accumulation of damage causes body systems to fail or slow down. This journal, by editor in chief Mikhail Blagosklonny is ranked third in documents that discuss aging. In early October, IntegraGen– a company that works on conversion of data from biological samples into genomic data and diagnostic tools for oncology– announced that Ocnotarget’s journal on the Expression Level of miR-31-3p with development-free survival in Metastatic Colorectal Cancer had been published. The article was explaining the relationship between of usefulness of anti-EGFR therapy and the standard of marker expression. Also featured were the remarks of the co-author and lead investigator of the research- John Primrose.

Primrose who is a Professor of surgery at the Southampton University expressed his delight in this achievement of being able to publish clinical data, which in the long term would help to customize therapeutic approaches and improve services that reached patients of metastatic colorectal cancer. Recent information had shown that colorectal cancer had become the third most common cancer and men and second in women. Every year, about 1.3 million new cases of the cancer are reported in the world. Of this, about 25% will be diagnosed with cancer at first diagnosis and 50% will develop it later after the diagnosis. The cancer had fast become the fourth cause of cancer-related deaths taking about 700,000 lives each year. The research would, therefore, help in saving so many lives.The miRpredX 31-3p kit that IntegraGen had of late announced its availability as a ready to use kit in testing FFPE tumors would also be helpful.

The miRpredX 31-3p was the first positive test for patients suffering from metastatic colorectal cancer. It would be used to predict the possible clinical benefit in the treatment of anti-EGFR therapy in comparison with anti-VEGF therapy in non-mutated RAS patients. IntegraGen is focused on providing researchers and tools that will see patient treatment improve. The company is based in Cambridge, USA.Oncotarget has become widely known since it was founded in 2010 as a peer-reviewed open access medical journal. It is published by the Impact Journals and covers research on the many aspects of oncology. The editors in chief of the journal are Andrei. V. Gudkov and Mikhail Blagosklonny of the Roswell Park Cancer Institute. They publish issues on a weekly basis, which can be printed for special demand. The journal looks to increase the impact of research through good and efficient reviews as well as to readily provide scientific research. Some of their other objectives include bridge the gap between specialties, create relationships between the fields of biomedical science as well as use clinical science to fight diseases.

Adam Milstein: An Exceptional Entrepreneur Cum Philanthropist

Adan Milstein is the managing partner of Hager Pacific Properties where he oversees the firm’s financing, disposition, and accounting sections.

Adam is a native of Israel, and he enrolled with Technion- Israel Institute of Technology. He received an undergraduate degree in Business and Economics in 1978. In 1981, Adam Milstein arrived in the United States to pursue a course in Masters of Business Administration in California Southern University. He graduated in 1983 and began a career in Commercial Real Estate.

Apart from being a real estate investor, Adam Milstein is active in philanthropy as well as an outstanding community leader. He is the founder and National Chairman of the Israeli- American Council. He chairs the group’s national expansion program. Adam Milstein also sits on the board of several organizations that have the aim of supporting the Jewish people and the State of Israel. Adam and his wife, Gila also founded an organization, Sifriyat Pijama B’America. The group distributes free monthly publications in Hebrew.

Adam Milstein is driven by the belief that for one to understand the issue by their self, they cannot rely on other people. Rather, one should be part of the solution through understanding the problem and contemplating the issue.

Therefore, when Adam realized that potential employers who had come recruiting just before his graduation were not concerned about his knowledge and experience, he decided to venture out alone. After just three years, Adam Milstein had become a successful Commercial Real Estate broker. This success saw him choose to become a real estate investor. This willingness to invest in real estate led to the creation of the Hagar Pacific Properties in 1986.

The sixty-four-year-old regards consistency, persistency, and follow-up as the main habits that have made him productive in entrepreneurship. Adam Milstein who also believes family is the most important, is influenced by his partner David Hagar. With a good view of the world and economic affairs together with being a great thinker with vision, Adam Milstein is awed by his partner’s qualities.

Adam Milstein advises prospective investors to follow up on every lead. From his experience, Adam also cautions against the mentality that success should be achieved rapidly. He rather stresses on patience and beginning of investment from scratch to the top.

Adam Milstein has done a remarkable job for Jewish-Americans through his philanthropic undertaking and is an inspiration to any aspiring entrepreneur.

How Patty Rocklage Renovated Her Home With Little Expense

Patty’s Background


Patty Rocklage is a licensed marriage and family therapist based in Sudbury, Massachusetts. She is wife to Scott Rocklage, a renowned healthcare services expert. She graduated from the University of Southern California in 1981 and boasts of over 20 years’ experience in the marriage counselling industry.


Rocklage Home Renovation


Patty Rocklage  and her husband toured Sudbury Kitchen and Bath show, and made an astounding discovery. Their home needed some face-lifting, and they were thinking of enlisting the services of subcontractors. They did not know that Ed Freelander, and Sudbury Kitchen and Bath employees were equally capable of renovating their home. They learnt of the merits of hiring Sudbury companies over subcontractors during the walk-in. The firm was able to examine their house and come up with a concrete plan on how to efficiently refurbish it. They would focus on reducing costs incurred without compromising the quality of output. Lots of time and resources would also be salvaged if they were to outsource to Sudbury Companies.


The disjoint between the kitchen and other rooms in the houses did not please the Rocklage’s. Ed came up with three solutions to this; shifting the kitchen to another room, renovate the existing kitchen or build an entirely new kitchen. Designers from the Sudbury companies drew colored artistic impressions and printed 3D models of three options, giving a vivid outlook of the expected results.


After assessing the three possible outcomes and revisiting their budget, the family decided to prioritize the redesign of the front door. The front façade was not accessible to guests, who often got lost while trying to locate it. The renovation of the Kitchen had to be momentarily put aside.


Ed designed the façade to be a three season porch. The porch would be optimized to receive sunlight when it’s rising and when it’s setting, according to Ed. The porch would also remain heated during winter season to combat chilly conditions.


Sudbury was also conserved in landscaping the project while conserving the environment. Due to the location of the home in a wetland buffer zone, relevant authorities had to be consulted before work could begin. After approval, Sudbury staff began the work. They removed over 20 truckloads of earth in a bid to level the area. The staff tried their best to finish their work before Christmas, but the bleak winter weather stood in their way.


The Rocklage’s were only seeking to refurbish their kitchen, but they ended up renovating the whole house. By entrusting the work to, Sudbury the family saved money and resources, with the project being completed in just six months.


Renovation of University Chemistry Laboratory


The Rocklage family made a significant donation towards the refurbishment of a chemistry lab in MIT. Scott said that the gift was a sign of the family’s gratitude for the quality education he received at the institution.